Postdoctoral Researcher - Cardiovascular research

Application deadline:

The Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P) – CNIC, is considering applications for a Post-doctoral position for the Molecular Cardiology Laboratory directed by Professor Silvia G Priori. The laboratory focuses on research of disease mechanisms and novel therapies for inherited arrhythmias like Long QT Syndrome, catecholaminergic polymorphic ventricular tachycardia (CPVT) and Brugada Syndrome. The models that are used span from induced Pluripotent Stem Cell (iPSC)-derived cardiac myocytes to isolated cardiac myocytes isolated from animal models, to genetically modified mice and swine models of diseases. We are searching for a highly motivated young scientist with the interest to engage in challenging research that aims to provide novel understanding of arrhythmic mechanisms and develop and test novel cures for patients. The selected candidate will be responsible for the design, development and implementation of protocols for the functional characterization of cell membrane electrophysiology (action potentials, membrane currents) and arrhythmogenic mechanisms (early and delayed after-depolarizations) in individual cardiomyocytes isolated from animal models of inherited arrhythmias or differentiated from induced-pluripotent stem cells. Engagement in the in vivo experiments including phenotypical characterization of animal’s models with echocardiography, electrocardiography and mapping of the heart electrical activity in vivo will be part of the tasks of the selected candidate. Experience in molecular biology techniques, especially site-directed mutagenesis, western blot, RNA-interference will be valued. The CNIC is a public research institute dedicated to excellence in cardiovascular research and to translating new knowledge into real improvements in clinical practice. This modern building is equipped with the latest scientific equipment, including state-of-the-art integrated set up for simultaneous patch clamp and confocal-based calcium imaging, and a comprehensive research-support infrastructure. The Foundation has a research center of 24,000 m2, located in Madrid, with more than 6,000 m2 for laboratories.